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Literature summary extracted from

  • Wong, C.H.; Wu, Z.; Yu, Q.
    CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis (2014), Oncogene, 33, 1249-1257.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.43 lysosome
-
 Homo sapiens 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.43 Homo sapiens O60911
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.43 colon
-
 Homo sapiens
-
3.4.22.43 colorectal cancer cell
-
 Homo sapiens
-
3.4.22.43 HCT-116 cell
-
 Homo sapiens
-
3.4.22.43 RKO cell
-
 Homo sapiens
-
3.4.22.43 SW-620 cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.22.43 cathepsin L2
-
 Homo sapiens
3.4.22.43 cathepsin like 2
-
 Homo sapiens
3.4.22.43 cathepsin V
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.22.43 Homo sapiens E2F1 activates cathepsin like 2 gene promoter activity up

General Information

EC Number General Information Comment Organism
3.4.22.43 malfunction RNAi-mediated depletion of the enzyme effectively abrogates ectopic E2F1-induced apoptosis, coupled with reduced lysosomal membrane permeabilization and mitochondrial membrane depolarization. Enzyme knockdown also inhibits apoptosis mediated by the endogenous E2F1 activated by DNA damage. Enzyme depletion in cancer cells results in inhibition of histone deacetylase inhibitor-induced apoptosis Homo sapiens
3.4.22.43 physiological function cathepsin like 2 is required for E2F1-induced apoptosis by engaging lysosomal membrane permeabilization. Its level also modulates the cellular sensitivity to histone deacetylase inhibitor Homo sapiens